Spasticity Management in Disorders of Consciousness

Authors: Martens G; Laureys S; Thibaut A. — Background: Spasticity is a motor disorder frequently encountered after a lesion involving the central nervous system. It is hypothesized to arise from an anarchic reorganization of the pyramidal and parapyramidal fibers and leads to hypertonia and hyperreflexia of the affected muscular groups. While this symptom and its […]

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Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

Authors: Caveliere C; Aiello M; Di Perri C; Amico E; Martial C; Thibaut A; Laureys S; Soddu A. — Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising […]

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Qualitative thematic analysis of the phenomenology of near-death experiences

Authors: Helena Cassol; Benoıt Petre; Sophie Degrange; Charlotte Martial; Vanessa Charland-Verville; Francois Lallier; Isabelle Bragard; Michèle Guillaume; Steven Laureys. — Near-death experiences (NDEs) refer to profound psychological events that can have an important impact on the experiencers’ (NDErs) lives. Previous studies have shown that NDEs memories are phenomenologically rich. In the present study, we therefore […]

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Global structural integrity and effective connectivity in patients with disorders of consciousness

Authors: Bodart O; Amico E; Gomes F; Casali A; Wannez S; Heine L; Thibaut A; Annen J; Boly M; Casarotto S; Rosanova M; Massimini M; Laureys S; Gosseries O. — BACKGROUND: Previous studies have separately reported impaired functional, structural, and effective connectivity in patients with disorders of consciousness (DOC). The perturbational complexity index (PCI) is […]

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Measures of metabolism and complexity in the brain of patients with disorders of consciousness

Authors: Bodart O; Gosseries O; Wannez S; Thibaut A; Annen J; Boly M; Rossanova M; Casali A; Casarotto S; Tononi G; Massimini M; Laureys S. — Background Making an accurate diagnosis in patients with disorders of consciousness remains challenging. 18F-fluorodeoxyglucose (FDG)–PET has been validated as a diagnostic tool in this population, and allows identifying unresponsive […]

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Transcranial Electric Stimulation for Precision Medicine: A Spatiomechanistic Framework

Authors: Yavari F; Nitsche M; Ekhtiari H. — During recent years, non-invasive brain stimulation, including transcranial electrical stimulation (tES) in general, and transcranial direct current stimulation (tDCS) in particular, have created new hopes for treatment of neurological and psychiatric diseases. Despite promising primary results in some brain disorders, a more widespread application of tES is […]

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Transcranial direct current stimulation unveils covert consciousness

Authors: Thibaut A; Chatelle C; Vanhaudenhuyse A; Martens G; Cassol H; Martial C; Carrière M; Barra A; Laureys S; Gosseries O. — Thanks to modern neuroimaging techniques it appears that 30% of clinically unresponsive patients (i.e., unresponsive wakefulness syndrome – UWS) retain cerebral functions that are similar to patients in a minimally conscious state – […]

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Objective assessment of visual pursuit in patients with disorders of consciousness: an exploratory study

Authors: Wannez S; Hoyoux T; Langohr T; Bodart O; Martial C; Wertz J; Chatelle C; Verly JG; Laureys S. — Visual pursuit is a key marker of residual consciousness in patients with disorders of consciousness (DOC). Currently, its assessment relies on subjective clinical decisions. In this study, we explore the variability of such clinical assessments, […]

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The repetition of behavioral assessments in diagnosis of disorders of consciousness

Authors: Wannez S; Heine L; Thonnard M; Gosseries O; Laureys S; Coma Science Group collaborators. — OBJECTIVE: To determine whether repeated examinations using the Coma Recovery Scale-Revised (CRS-R) have an impact on diagnostic accuracy of patients with disorders of consciousness and to provide guidelines regarding the number of assessments required for obtaining a reliable diagnosis. […]

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Prevalence of coma-recovery scale-revised signs of consciousness in patients in minimally conscious state

Authors: Wannez S; Gosseries O; Azzolini D; Martial C; Cassol H; Aubinet C; Annen J; Martens G; Bodart O; Heine L; Charland-Verville V; Thibaut A; Chatelle C; Vanhaudenhuyse A; Demertzi A; Schnakers C; Donneau AF; Laureys S. — Different behavioural signs of consciousness can distinguish patients with an unresponsive wakefulness syndrome from patients in minimally […]

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