Personalization of hybrid brain models from neuroimaging and electrophysiology data

Authors: R. Sanchez-Todo, R. Salvador, E. Santarnecchi, F. Wendling, G. Deco, G. Ruffini – Personalization is rapidly becoming standard practice in medical diagnosis and treatment. This study is part of an ambitious program towards computational personalization of neuromodulatory interventions in neuropsychiatry. We propose to model the individual human brain as a network of neural masses […]

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Realistic modeling of ephaptic fields in the human brain

Authors: Giulio Ruffini, Ricardo Salvador, Ehsan Tadayon, Roser Sanchez-Todo, Alvaro Pascual-Leone, Emiliano Santarnecchi – Several decades of research suggest that weak electric fields may influence neural processing, including those induced by neuronal activity and recently proposed as substrate for a potential new cellular communication system, i.e., ephaptic transmission. Here we aim to map ephaptic activity […]

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Convolutional neural network MRI segmentation for fast and robust optimization of transcranial electrical current stimulation of the human brain

Authors: Carla Sendra-Balcells, ProfileRicardo Salvador, Juan B. Pedro, M C Biagi, ProfileCharlène Aubinet, Brad Manor, Aurore Thibaut, Steven Laureys, ProfileKarim Lekadir, ProfileGiulio Ruffini – The segmentation of structural MRI data is an essential step for deriving geometrical information about brain tissues. One important application is in transcranial direct current stimulation (e.g., tDCS), a non-invasive neuromodulatory […]

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Characterization of near death experiences using text mining analyses: A preliminary study

Authors: Vanessa Charland-Verville, Demetrius Ribeiro de Paula, Charlotte Martial, Helena Cassol, Georgios Antonopoulos, Blaine Alexander Chronik, Andrea Soddu , Steven Laureys – The notion that death represents a passing to an afterlife, where we are reunited with loved ones and live eternally in a utopian paradise, is common in the reports of people who have […]

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Clinical and electrophysiological investigation of spastic muscle overactivity in patients with disorders of consciousness following severe brain injury

Authors: Martens G, Deltombe T, Foidart-Dessalle M, Laureys S, Thibaut A. – Objective: The clinical and electrophysiological profile of spastic muscle overactivity (SMO) is poorly documented in patients with disorders of consciousness (DOC) following severe cortical and subcortical injury. We aim at investigating the link between the clinical observations of SMO and the electrophysiological spastic […]

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Reappearance of Command-Following Is Associated With the Recovery of Language and Internal-Awareness Networks: A Longitudinal Multiple-Case Report

Authors: Charlène Aubinet, Rajanikant Panda, Stephen Karl Larroque, Helena Cassol, Mohamed Ali Bahri, Manon Carrière, Sarah Wannez, Steve Majerus, Steven Laureys and Aurore Thibaut – The recovery of patients with disorders of consciousness is a real challenge, especially at the chronic stage. After a severe brain injury, patients can regain some slight signs of consciousness, […]

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